By now the coronavirus pandemic has influenced the life in each and every country in the world. In the Danube Region, the emergency measures against a further spread of the COVID-19 disease are, however, producing mixed results. The current crisis shows a diversity of approaches that the countries have undertaken, as well as different capabilities in coping with the invisible danger. We have arrived at the historical crossroads, where not only our immune systems but also our very foundations of democracy as well as tools for cooperation are challenged. We will provide an overview on the different reactions by governments in the Danube Region to the outbreak of the virus and offer recommendations for future political developments resulting from these initial observations.